Hydroxylapatit in der Zahnpflege

Zahlreiche Studien zeigen die Wirksamkeit hydroxylapatithaltiger Produkte im Bereich Zahnpflege und Prophylaxe (in vivo, in situ und in vitro Studien).

Übersichten in zahnmedizinischen Fachbüchern

  • Loveren, C. v. Toothpastes. Vol. 23 (Karger, 2013).
  • Gillam, D. G. Dentine hypersensitivity: Advances in diagnosis, management, and treatment. (Springer International Publishing, 2015).


Studien: Kariesprophylaxe, Biofilmkontrolle, Plaqueentfernung, Zahnfleischschutz


  • Harks, I. et al. Impact of the daily use of a microcrystal hydroxyapatite dentifrice on de novo plaque formation and clinical/microbiological parameters of periodontal health. A randomized trial. PloS one 11, e0160142 (2016).
  • Hegazy, S. A. & Salama, I. R. Antiplaque and remineralizing effects of Biorepair mouthwash: A comparative clinical trial. Pediatr. Dent. J. 26, 89-94 (2016).
  • Brambilla, E., Ionescu, A., Cazzaniga, G., Edefonti, V. & Gagliani, M. The influence of antibacterial toothpastes on in vitro Streptococcus mutans biofilm formation: a continuous culture study. Am. J. Dent. 27, 160-166 (2014).
  • Hannig, C., Basche, S., Burghardt, T., Al-Ahmad, A. & Hannig, M. Influence of a mouthwash containing hydroxyapatite microclusters on bacterial adherence in situ. Clin. Oral Investig. 17, 805-814 (2013).
  • Palmieri, C., Magi, G., Orsini, G., Putignano, A. & Facinelli, B. Antibiofilm activity of zinc-carbonate hydroxyapatite nanocrystals against Streptococcus mutans and mitis group Streptococci. Curr. Microbiol. 67, 679-681 (2013).
  • Najibfard, K., Ramalingam, K., Chedjieu, I. & Amaechi, B. T. Remineralization of early caries by a nano-hydroxyapatite dentifrice. J. Clin. Dent. 22, 139-143 (2011).
  • Itthagarun, A., King, N. M. & Cheung, Y.-M. The effect of nano-hydroxyapatite toothpaste on artificial enamel carious lesion progression: an in-vitro pH-cycling study. Hong Kong Dent. J. 7, 61-66 (2010).
  • Huang, S. B., Gao, S. S. & Yu, H. Y. Effect of nano-hydroxyapatite concentration on remineralization of initial enamel lesion in vitro. Biomed. Mater. 4,034104/034101-034104/034106 (2009).
  • Lu, K., Meng, X., Zhang, J., Li, X. & Zhou, M. Inhibitory effect of synthetic nano-hydroxyapatite on dental caries. Key Eng. Mater. 336-338, 1538-1541 (2007).
  • Lv, K., Zhang, J., Meng, X. & Li, X. Remineralization effect of the nano-HA toothpaste on artificial caries. Key Eng. Mater. 330-332, 267-270 (2007).
  • Jeong, S. H. et al. Remineralization potential of new toothpaste containing nano-hydroxyapatite. Key Eng. Mater. 309-311, 537-540 (2006).
  • Onuma, K., Yamagishi, K. & Oyane, A. Nucleation and growth of hydroxyapatite nanocrystals for nondestructive repair of early caries lesions. J. Cryst. Growth 282, 199-207 (2005).
  • Kani, K. et al. Effect of apatite-containing dentifrices on dental caries in school children. J. Dent. Health 19, 104-109 (1989).
  • Kani, T. et al. The effect of apatite-containing dentifrices on artificial caries lesions. J. Dent. Health 38, 364-366 (1988).
  • Studien: Reparatur mikrofeiner Defekte im Zahnschmelz und Erosionsschutz
  • Min, J. H., Kwon, H. K. & Kim, B. I. Prevention of dental erosion of a sports drink by nano-sized hydroxyapatite in situ study. Int. J. Paediatr. Dent. 25, 61-69 (2015).
  • Bonetti, G. A., Pazzi, E., Zanarini, M., Marchionni, S. & Checchi, L. The effect of zinc-carbonate hydroxyapatite versus fluoride on enamel surfaces after interproximal reduction. Scanning 36, 356-361 (2014).
  • Lelli, M. et al. Remineralization and repair of enamel surface by biomimetic Zn-carbonate hydroxyapatite containing toothpaste: a comparative in vivo study. Front. Physiol. 5, 333 (2014).
  • Mielczarek, A. & Michalik, J. The effect of nano-hydroxyapatite toothpaste on enamel surface remineralization. An in vitro study. Am. J. Dent. 27, 287-290 (2014).
  • Poggio, C., Lombardini, M., Vigorelli, P., Colombo, M. & Chiesa, M. The role of different toothpastes on preventing dentin erosion: An SEM and AFM study. Scanning 36, 301-310 (2014).
  • Gjorgievska, E. S., Nicholson, J. W., Slipper, I. J. & Stevanovic, M. M. Remineralization of demineralized enamel by toothpastes: A scanning electron microscopy, energy dispersive x-ray analysis, and three-dimensional stereo-micrographic study. Microsc. Microanal. 19, 587-595 (2013).
  • Sadiasa, A. et al. Addition of hydroxyapatite to toothpaste and its effect to dentin remineralization. Han'guk Chaelyo Hakhoechi 23, 168-176 (2013).
  • Swarup, J. S. & Rao, A. Enamel surface remineralization: using synthetic nanohydroxyapatite. Contemp. Clin. Dent. 3, 433-436 (2012).
  • Haghgoo, R., Abbasi, F. & Rezvani, M. B. Evaluation of the effect of nanohydroxyapatite on erosive lesions of the enamel of permanent teeth following exposure to soft beer in vitro. Sci. Res. Essays 6, 5933-5936 (2011).
  • Huang, S., Gao, S., Cheng, L. & Yu, H. Remineralization potential of nano-hydroxyapatite on initial enamel lesions: An in vitro study. Caries Res. 45, 460-468 (2011).
  • Li, L. et al. Bio-inspired enamel repair via Glu-directed assembly of apatite nanoparticles: an approach to biomaterials with optimal characteristics. Adv. Mater. 23, 4695-4701 (2011).
  • Min, J. H., Kwon, H. K. & Kim, B. I. The addition of nano-sized hydroxyapatite to a sports drink to inhibit dental erosion: in vitro study using bovine enamel. J. Dent. 39, 629-635 (2011).
  • Tschoppe, P., Zandim, D. L., Martus, P. & Kielbassa, A. M. Enamel and dentine remineralization by nano-hydroxyapatite toothpastes. J. Dent. 39, 430-437 (2011).
  • Poggio, C., Lombardini, M., Colombo, M. & Bianchi, S. Impact of two toothpastes on repairing enamel erosion produced by a soft drink: An AFM in vitro study. J. Dent. 38, 868-874 (2010).
  • Roveri, N. et al. Surface enamel remineralization: biomimetic apatite nanocrystals and fluoride ions different effects. J. Nanomater. (2009).
  • Ryu, S.-C. et al. Regeneration of a micro-scratched tooth enamel layer by nanoscale hydroxyapatite solution. Bull. Korean Chem. Soc. 30, 887-890 (2009).
  • Li, L. et al. Repair of enamel by using hydroxyapatite nanoparticles as the building blocks. J. Mater. Chem. 18, 4079-4084 (2008).
  • Roveri, N. et al. Synthetic biomimetic carbonate-hydroxyapatite nanocrystals for enamel remineralization. Adv. Mater. Res. 47-50, 821-824 (2008).
  • Yamagishi, K. et al. Materials chemistry: a synthetic enamel for rapid tooth repair. Nature 433, 819 (2005).


Studien: Schutz vor schmerzempfindlichen Zahnhälsen

  • Oliveira, D. W. D. d. et al. Effectiveness of three desensitizing dentifrices on cervical dentin hypersensitivity: A pilot clinical trial. J. Int. Acad. Periodontol. 18, 57-65 (2016).
  • Wang, L. et al. Treatment of dentin hypersensitivity using nano-hydroxyapatite pastes: A randomized three-month clinical trial. Oper. Dent. (2016).
  • Amaechi, B. T., Mathews, S. M., Ramalingam, K. & Mensinkai, P. K. Evaluation of nanohydroxyapatite-containing toothpaste for occluding dentin tubules. Am. J. Dent. 28, 33-39 (2015).
  • Farooq, I., I. A. Moheet, I. A. & E. AlShwaimi, E. In vitro dentin tubule occlusion and remineralization competence of various toothpastes. Arch. Oral Biol. 60, 1246-1253 (2015).
  • Genovesi, A. M. et al. In vitro comparison of three desensitizing prophylaxis pastes: a morphological analysis. J. Oral Hyg. Health 3, 1000186 (2015).
  • Gopinath, M. M., Kumar, E. S., John, J., Nagappan, N. & Prabhu, S. Evaluation of dentifrice containing nano-hydroxyapatite for dentinal hypersensitivity: A randomized controlled trial. J. Int. Oral Health. 7, 118-122 (2015).
  • Vano, M., Derchi, G., Barone, A., Genovesi, A. & Covani, U. Tooth bleaching with hydrogen peroxide and nano-hydroxyapatite: a 9-month follow-up randomized clinical trial. Int. J. Dent. Hyg. 13, 301-307 (2015).
  • Vano, M., Derch, G., Barone, A. & Covani, U. Effectiveness of nano-hydroxyapatite toothpaste in reducing dentin hypersensitivity: a double-blind randomized controlled trial. Quintessence Int. 45, 703-711 (2014).
  • Orsini, G. et al. A 3-day randomized clinical trial to investigate the desensitizing properties of three dentifrices. J. Periodontol. 84, 65-73 (2013).
  • Browning, W. D., Cho, S. D. & Deschepper, E. J. Effect of a nano-hydroxyapatite paste on bleaching-related tooth sensitivity. J. Esthet. Restor. Dent. 24, 268-276 (2012).
  • Yuan, P. et al. Effects of dentifrice containing hydroxyapatite on dentinal tubule occlusion and aqueous hexavalent chromium cations sorption: a preliminary study. PloS one 7, e45283 (2012).
  • Orsini, G. et al. A double-blind randomized-controlled trial comparing the desensitizing efficacy of a new dentifrice containing carbonate/hydroxyapatite nanocrystals and a sodium fluoride/potassium nitrate dentifrice. J. Clin. Periodontol. 37, 510-517 (2010).
  • Shetty, S., Kohad, R. & Yeltiwar, R. Hydroxyapatite as an in-office agent for tooth hypersensitivity: a clinical and scanning electron microscopic study. J. Periodontol. 81, 1781-1789 (2010).
  • Lee, S. Y., Kwon, H. K. & Kim, B. I. Effect of dentinal tubule occlusion by dentifrice containing nano-carbonate apatite. J. Oral Rehabil. 35, 847-853 (2008).
  • Hüttemann, R. W. & Dönges, H. Untersuchungen zur Therapie überempfindlicher Zahnhälse mit Hydroxylapatit. Dtsch. Zahnärztl. Z. 42, 486-488 (1987).