Karex with hydroxyapatite:

Oral care for modern caries prevention

Caries still remains the most significant type of dental disease.1

The risk factors for caries are, in particular, sugary foodstuffs and inadequate plaque removal.2,3 There are, however, other factors that can significantly increase the risk of caries.

Demographic changes have resulted in an aging population. As we age, the amount of medication we take also increases. Numerous medications that are taken on a day-to-day basis and other factors, such as stress and certain illnesses, can result in a reduction of saliva. 4-6

Examples of medication that can lead to a reduction of saliva are:

  • Antidepressants
  • Betablockers and other antihypertensive agents
  • Antihistamines (antiallergic medication)
  • Painkillers
  • Antibiotics

When saliva is reduced, the natural remineralisation process from saliva is restricted and the risk of caries is increased. There is too little calcium phosphate from the saliva.3

Karex with hydroxyapatite

Hydroxyapatite is the natural building block of dental enamel and is therefore of particular interest in oral care as a biomimetic agent.7

Karex with hydroxyapatite offers protection using an anti-caries active complex:

  • Regeneration and protection of the enamel8-15
  • Modern biofilm management16
  • Plaque removal17

Karex contains hydroxyapatite and is therefore effective even when saliva is reduced. This is because the active ingredient is already present in mineral form and does not have to be formed from the saliva through remineralisation processes.10 Moreover, Karex with hydroxyapatite repairs microfine defects in the tooth surface and forms a protective layer to prevent caries.

The latest clinical study confirms effectiveness in caries prevention

A successfully concluded randomised and placebo- controlled study of a caries-active risk group confirmed the effective protection against caries.18 The hydroxyapatite toothpaste was just as effective as a toothpaste with amine fluoride / stannous fluoride, the “gold standard” for caries prophylaxis.

Based on a risk group of patients undergoing orthodontic treatment at five German university hospitals, it was successfully demonstrated that a hydroxyapatitebased toothpaste is just as effective in terms of caries prophylaxis as a reference product containing amine fluoride and stannous fluoride (in total 1400 ppm fluoride). The study comprised a total of 150 subjects. The caries was assessed using the modern International Caries Detection and Assessment System (ICDAS).19

  1. Listl, S., Galloway, J., Mossey, P. A. & Marcenes, W. Global economic impact of dental diseases. J. Dent. Res. 94, 1355-1361 (2015).
  2. Meyer-Lückel, H., Paris, S. & Ekstrand, K. Karies: Wissenschaft und Klinische Praxis. (Thieme, 2012). 
  3. Fejerskov, O. & Kidd, E. Dental Caries: The Disease and its Clinical Management. (Wiley, 2009). 
  4. Sreebny, L. M. & Schwartz, S. S. A reference guide to drugs and dry mouth - 2nd edition. Gerodontology 14, 33-47 (1997). 
  5. Guggenheimer, J. & Moore, P. A. Xerostomia: etiology, recognition and treatment. J. Am. Dent. Assoc. 134, 61-69 (2003). 
  6. Villa, A., Connell, C. L. & Abati, S. Diagnosis and management of xerostomia and hyposalivation. Ther. Clin. Risk Manag. 11, 45-51 (2015). 
  7. Enax, J. & Epple, M. Synthetic hydroxyapatite as a biomimetic oral care agent. Oral Health Prev. Dent. (accepted). 
  8. Kani, K. et al. Effect of apatite-containing dentifrices on dental caries in school children. J. Dent. Health 19, 104-109 (1989). 
  9. Lelli, M. et al. Remineralization and repair of enamel surface by biomimetic Zn-carbonate hydroxyapatite containing toothpaste: a comparative in vivo study. Front. Physiol. 5, 333 (2014). 
  10. Najibfard, K., Ramalingam, K., Chedjieu, I. & Amaechi, B. T. Remineralization of early caries by a nano-hydroxyapatite dentifrice. J. Clin. Dent. 22, 139-143 (2011). 
  11. Tschoppe, P., Zandim, D. L., Martus, P. & Kielbassa, A. M. Enamel and dentine remineralization by nano-hydroxyapatite toothpastes. J. Dent. 39, 430-437 (2011). 
  12. Loveren, C. v. Toothpastes. Vol. 23 (Karger, 2013). 
  13. Roveri, N. et al. Synthetic biomimetic carbonate-hydroxyapatite nanocrystals for enamel remineralization. Adv. Mater. Res. 47-50, 821-824 (2008).
  14. Yamagishi, K. et al. Materials chemistry: a synthetic enamel for rapid tooth repair. Nature 433, 819 (2005). 
  15. Hegazy, S. A. & Salama, I. R. Antiplaque and remineralizing effects of Biorepair mouthwash: A comparative clinical trial. Pediatr. Dent. J. 26, 89-94 (2016). 
  16. Hannig, C., Basche, S., Burghardt, T., Al-Ahmad, A. & Hannig, M. Influence of a mouthwash containing hydroxyapatite microclusters on bacterial adherence in situ. Clin. Oral Investig. 17, 805-814 (2013). 
  17. Harks, I. et al. Impact of the daily use of a microcrystal hydroxyapatite dentifrice on de novo plaque formation and clinical/microbiological parameters of periodontal health. A randomized trial. PloS one 11, e0160142 (2016). 
  18. „Guter Rat“ - Das unabhängige Verbrauchermagazin (12.2016). 
  19. www.icdas.org.

KAREX toothpaste

with hydroxyapatite

Daily tooth brushing with Karex toothpaste helps to promote the regeneration of weakened enamel areas and the formation of a protective layer. Due to its saliva-neutral pH, Karex is particularly gentle on the teeth. Moreover, Karex toothpaste cleans the teeth thoroughly and effectively combats bacterial dental plaque. Use: 2 x daily for 2 minutes.

KAREX mouthwash

with hydroxyapatite

The Karex mouthwash boosts the effectiveness of the Karex toothpaste. Thanks to its gel-like consistency, the mouthwash adheres well to the tooth enamel to promote its regeneration. With its active complex of hydroxyapatite, zinc and xylitol, it has an antimicrobial effect and also prevents dental plaque.