Studies and scientific information
Here you will find a compilation of the most important studies. For further studies, please check out our study database.
Benefits of fluoride-free toothpastes
Prof. (emeritus) Dr Hardy Limeback reports on the benefits of using fluoride-free toothpastes with hydroxyapatite.
Long-term clinical study: Caries prevention with BioHAP
The multicentre clinical study showed that a toothpaste with BioHAP is just as effective for caries prophylaxis as the adult toothpaste with 1,450 ppm fluoride.
Efficacy of BioHAP in caries prophylaxis
A systematic review with meta-analysis examined the efficacy of BioHAP. The result: BioHAP is as effective as fluoride in caries prophylaxis.
Caries prophylaxis in milk teeth with BioHAP
A clinical, multicentre, double-blind, randomised study has proven the effectiveness of BioHAP in primary teeth.
General review on BioHAP
Review, published in “ZWR – Das Deutsche Zahnärzteblatt” [The German Dental Journal], summarises the published in vivo, in situ and in vitro studies on BioHAP in dental care.
BioHAP releases Calcium
BioHAP supplies calcium to protect our teeth and also ensures that the acids from caries bacteria are weakened.
Fraunhofer Institute and Dr. Wolff Research show: BioHAP brightens the teeth
A gel with BioHAP results in brighter teeth, while being gentle and non-abrasive. This effect is visible after just the first application.
A gel with BioHAP for cavity protection
A highly concentrated gel with BioHAP is just as effective as a highly concentrated fluoride gel in remineralising caries.
Deep-layer remineralization with BioHAP
A children’s toothpaste with BioHAP is just as effective at remineralising (initial) carious lesions as a children’s toothpaste with fluoride. BioHAP even results in deeper remineralisation compared to conventional toothpastes.
Max-Planck-Scientists prove the adhesion of BioHAP to enamel
BioHAP forms a protective layer on the surface of the teeth. This protective layer makes it difficult for bacteria and acids to attack the natural enamel.
Clinical trial proves efficacy on cavity protection using BioHAP
A BioHAP toothpaste is clinically as effective in caries prophylaxis as a fluoride toothpaste. The study was conducted at 5 German university hospitals.
Early childhood caries: Epidemiology, aetiology and prevention
The frequently cited current review on dental care in children describes the reasons for early childhood caries (ECC). Calcium phosphates in dental care products for use at home are recommended to prevent ECC.
BioHAP protects teeth from bacteria
BioHAP is highly effective in controlling the biofilm and does not affect the ecological balance.
Further scientific publications
Significance of hydroxyapatite in oral care