Skip to Footer
Logo KAREX
A blonde toddler in a light blue T-shirt has toothpaste in their mouth as a symbol of dental care for children.A blonde toddler in a light blue T-shirt has toothpaste in their mouth as a symbol of dental care for children.

Children's Toothpaste with BioHAP Instead of Fluoride

Nearly one in four children suffers from fluorosis. KAREX Toothpaste and gel with BioHAP instead of fluoride are easy to use, effectively prevent cavities, and can reduce fluoride sources.

  • Clinically confirmed cavity protection for baby teeth

  • Fluoride-free formula reduces the risk of fluorosis

  • Remineralizes teeth & minimizes bacterial adhesion

Studies: BioHAP is just as effective as fluoride in cavity prevention

  • Clinical study: 291

    studies were identified that investigated BioHAP in the context of dental care.

    BioHAP is just as effective as fluoride in caries prevention.

  • Clinical study: 90 %

    caries-free patients while using toothpaste with BioHAP.

    The gel with BioHAP was just as effective in remineralizing caries as the fluoride-containing adult toothpaste (88% caries-free patients).

  • Clinical study: 100 %

    of parents use too much fluoride-containing toothpaste for their children.

    The results of the study showed that the average amounts of toothpaste used by parents were significantly higher than the rice grain-sized recommended dose.
    For toothpaste with BioHAP, there are no dosage restrictions.

  • Clinical study: 39.3 %

    of parents are not informed about the conditions of use and warnings of fluoride toothpastes.

    The study shows that parents overdose fluoride-containing toothpastes. This leads to increased fluoride intake, which can result in fluorosis.

  • Further studies & research findings

Guide: Children's Dental Care in Focus

Nearly half of all first-grade children, including you or your child, have already had cavities. Learn more about cavities, fluorosis, and the right dental care for children.

  • A mother is brushing her toddler’s teeth with a toothpaste that contains BioHAP instead of fluoride, symbolizing the prevention of cavities in children

    Cavities in children: What you need to know!

    Cavities in your child? Find out how you can prevent them and keep your child’s teeth healthy. Discover the best tips now!

  • A girl in a blue and white striped top is smiling at the camera; white spots can be seen on her front teeth, which are signs of fluorosis, an enamel defect caused by excessive fluoride intake

    Fluorosis: Understanding and treating the causes

    Discover the causes of fluorosis and find out how you can treat it effectively. Protect your teeth and learn what you can do to prevent fluorosis!

  • A young girl with reddish-blonde hair is standing in the bathroom brushing her teeth with a toothbrush, symbolizing proper dental care during tooth transition in children

    Tooth transition in children: How to support your child from baby teeth to permanent teeth

    Help your child during tooth transition and find out how you can optimally support this important process. Discover tips and tricks for a smooth tooth transition now!

BioHAP benefits: What exactly is BioHAP?

KAREX – consciously with BioHAP instead of fluoride

BioHAP is hydroxyapatite – the substance our teeth are made of. But BioHAP also stands for effective cavity protection without risk: the alternative for children and for everyone who does not want fluoride in their toothpaste.

FAQ: Answers to Your Questions

The use of fluoride in toothpaste is particularly controversial for children under 6 years of age. Children in particular swallow a large portion of the toothpaste.

Due to the intake of additional sources of fluoride (vitamin D supplements with fluoride, fluoridated salt, etc.), the risk of developing fluorosis (white spots on the teeth caused by increased fluoride intake) increases significantly. For example, the German Federal Institute for Risk Assessment points out that if a children’s toothpaste with 500 ppm fluoride is swallowed, just as much fluoride is ingested as, for instance, through fluoridated salt.

According to the new recommendations, the amount of swallowed fluoride can therefore double. The risk of fluorosis is significantly higher with toothpastes that have a higher fluoride content (from 1000 ppm).

KAREX relies on the tooth-related active ingredient Hydroxyapatite (BioHAP) in all products. When swallowed, it is simply dissolved in the stomach. Numerous studies confirm its effectiveness: Hydroxyapatite repairs enamel with every brushing, reduces bacterial adhesion, and thus provides effective protection against cavities.

Our tooth enamel consists almost entirely of Hydroxyapatite. That is why BioHAP (biomimetic Hydroxyapatite) is used as an active ingredient in oral care. The highly concentrated active ingredient also serves as a source of calcium and protects our teeth against bacterial acids. Numerous studies confirm the benefits of Hydroxyapatite in the field of oral care and prevention.

Yes, BioHAP protects just as effectively as fluoride against cavities. BioHAP forms a protective layer on the tooth surface that prevents bacteria from adhering to the tooth and thus helps prevent cavities and gum inflammation. In addition, BioHAP releases calcium during acid attacks, which protects the teeth.

In contrast to many other fluoride-free toothpastes, KAREX uses Hydroxyapatite (BioHAP) as its active ingredient. This is the substance our teeth are made of. BioHAP protects at least as effectively against cavities as fluoride – without the risks of overdosing.

KAREX is “Made in Germany” and is developed and distributed by the Dr. Wolff Group, a fourth-generation family-owned company based in Bielefeld.

You probably already know one of our other strong brands such as Alpecin, ALCINA, Plantur, Linola, Bioniq® or V-san. You can find out more about us at drwolffgroup.com.

Numerous publications confirm the effectiveness of BioHAP in dental care. These include not only laboratory studies (in vitro) but also studies with test specimens under oral cavity conditions (in situ), as well as, in particular, clinical studies on patients (in vivo).
For more information, feel free to read the German short summary or the original study. You can get an overview of the large number of studies on Hydroxyapatite as an active ingredient in dental care by browsing our study database (usable without registration).

Limeback, H., Enax, J. & Meyer, F. (2021): Biomimetic hydroxyapatite and caries prevention: a systematic review and meta-analysis. Can J Dent Hyg. 2021 Oct 1;55(3):148–159.

Amaechi, B.T., AbdulAzees, P.A., Okoye, L.O. et al. (2020) Comparison of hydroxyapatite and fluoride oral care gels for remineralization of initial caries: a pH-cycling study. BDJ Open 6, 98-159

Sudradjat, H., Meyer, F., Fandrich, P. et al. (2024): Doses of fluoride toothpaste for children up to 24 months. BDJ Open 10, 7