KAREX: BioHAP – The Next Generation of Tooth Protection
Fluoride has long been used in cavity prevention, but it can carry risks — especially for children. KAREX is therefore taking a new approach: We rely on BioHAP, the scientifically proven active ingredient that prevents cavities just as effectively as fluoride — but without the risks. This makes KAREX the modern, safe choice for tooth protection for everyone — from the very first tooth.
Products: Ideal for Children: Cavity Protection Without Risk
Find your KAREX
The Direct Comparison
Fluoride Risks: Fluoride Risks in Focus
Fluorosis
IQ Reduction
Risks During Pregnancy
Alzheimer's disease
BioHAP: Modern Dental Care for Children: With KAREX and BioHAP
What kind of active ingredient is BioHAP?
BioHAP stands for biomimetic Hydroxyapatite — the main component of our natural tooth enamel.
BioHAP helps protect against cavities and remineralize damaged tooth enamel.
Recommended: Canadian Dental Association Confirms Efficacy of BioHAP Against Cavities
Clinically confirmed: KINDER KAREX Toothpaste is the first and only fluoride-free toothpaste with Hydroxyapatite to be approved in Canada by the health authorities (Health Canada) as an anti-cavity toothpaste. It is therefore a so-called "Natural Health Product." This product status can only be achieved when scientifically sound clinical data on efficacy and safety are available. In addition, the efficacy of the toothpaste with Hydroxyapatite has been confirmed by the Canadian Dental Association (CDA).
The Benefits of BioHAP
Cavity protection proven by studies
Numerous scientific publications confirm the effect of Hydroxyapatite in oral care. BioHAP is at least as effective as fluoride in cavity prevention.
Safe use
Small children usually cannot spit out toothpaste properly yet and swallow a large portion of it – with BioHAP this is harmless. No strict dosage requirements as with fluoride-containing toothpastes.
Reduced risk of fluorosis
The permanent damage to tooth enamel (fluorosis) is caused by an overdose of fluoride. KAREX is effective without fluoride. Toothpaste with BioHAP can be swallowed without hesitation.
ᑎ Fluoride Action Network (FAN), 2015. Submission to the National Toxicology Program: Review of fluoride for non-cancer health outcomes, including developmental neurotoxicity and endocrine disruption.
ᐳ Bai, R., Huang, Y., Wang, F., & Guo, J., 2020. Associations of fluoride exposure with sex steroid hormones among U.S. children and adolescents, NHANES 2013–2016. Environmental Pollution, 260, p.114003. doi: 10.1016/j.envpol.2020.114003.
ᑐ National Institute of Dental and Cranofacial Research: The Story of Fluoridation
ᕒ Pawinska, M., Paszynska, E., Amaechi, B. T., Meyer, F., Enax, J., & Limeback, H. (2024): Clinical evidence of caries prevention by hydroxyapatite: An updated systematic review and meta-analysis. Journal of Dentistry, 151