Cavity protection for permanent teeth. With BioHAP instead of fluoride
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Original article:
Original article:
The use of fluoride in toothpaste is particularly controversial for children under 6 years of age. Children in particular swallow a large portion of the toothpaste.
Due to the intake of additional sources of fluoride (vitamin D supplements with fluoride, fluoridated salt, etc.), the risk of developing fluorosis (white spots on the teeth caused by increased fluoride intake) increases significantly. For example, the German Federal Institute for Risk Assessment points out that if a children’s toothpaste with 500 ppm fluoride is swallowed, just as much fluoride is ingested as, for instance, through fluoridated salt.
According to the new recommendations, the amount of swallowed fluoride can therefore double. The risk of fluorosis is significantly higher with toothpastes that have a higher fluoride content (from 1000 ppm).
KAREX relies on the tooth-related active ingredient Hydroxyapatite (BioHAP) in all products. When swallowed, it is simply dissolved in the stomach. Numerous studies confirm its effectiveness: Hydroxyapatite repairs enamel with every brushing, reduces bacterial adhesion, and thus provides effective protection against cavities.
Our tooth enamel consists almost entirely of Hydroxyapatite. That is why BioHAP (biomimetic Hydroxyapatite) is used as an active ingredient in oral care. The highly concentrated active ingredient also serves as a source of calcium and protects our teeth against bacterial acids. Numerous studies confirm the benefits of Hydroxyapatite in the field of oral care and prevention.
▲ Limeback, H., Enax, J. & Meyer, F. (2021): Biomimetic hydroxyapatite and caries prevention: a systematic review and meta-analysis. Can J Dent Hyg. 2021 Oct 1;55(3):148–159.
◓ Amaechi, B.T., AbdulAzees, P.A., Okoye, L.O. et al. (2020) Comparison of hydroxyapatite and fluoride oral care gels for remineralization of initial caries: a pH-cycling study. BDJ Open 6, 98-159
△ Sudradjat, H., Meyer, F., Fandrich, P. et al. (2024): Doses of fluoride toothpaste for children up to 24 months. BDJ Open 10, 7
JUNIOR KAREX is the ideal toothpaste for the daily brushing of the first permanent teeth: By repairing tooth enamel, it effectively protects against cavities and also helps with chalky teeth (MIH) – with BioHAP instead of fluoride.
Chalk teeth (MIH) are a completely new challenge that many parents and dentists are facing. The molars ("M") and incisors ("I") are not sufficiently developed ("Hypomineralization"). According to current figures, over 30% of 12-year-olds show this condition of porous teeth.
Unlike healthy permanent teeth, chalk teeth are not fully mineralized. Normally, tooth enamel consists of approximately 97% Hydroxyapatite — a calcium-containing compound. This Hydroxyapatite is already formed while the teeth are not yet visible in the oral cavity. Many different proteins are responsible for the formation of healthy, hard tooth enamel, and these proteins do not function properly in chalk teeth.
Unfortunately, researchers and dentists are in the dark when it comes to the exact cause of chalk teeth in children. Plasticizers in plastic are frequently cited as a cause of chalk teeth. However, infectious diseases, upper respiratory tract infections, medications such as antibiotics are also considered. Environmental toxins are also not ruled out as a cause of chalk teeth.
Chalk teeth are uncomfortable and often painful for children. Depending on the severity, it is decided whether the teeth should be preserved, restored, or extracted. Dentists frequently apply high-concentration fluoride varnish, which is meant to protect against cavities but does not repair chalk teeth. Toothpaste with BioHAP, on the other hand, replenishes the calcium deficit and forms a protective layer of Hydroxyapatite. This not only protects chalk teeth from cavities but also reduces their sensitivity to pain.
Fluoride is a widely distributed mineral that we absorb through food and water. It is not an essential nutrient; while it protects against cavities, an overdose can quickly lead to fluorosis or other health problems.
Fluoride is omnipresent in our daily livesᑎ: toothpaste, tea, fish with bones, fluoridated salt, seafood, mineral water, grain products.
Since 2015, the U.S. National Toxicology Program (NTP) has been investigating the effects of fluoride on neurotoxicity and endocrine disruption. The brain responds sensitively at 1–2 mg/l, the thyroid gland at 2–4 mg/l.ᑎ
The correct toothpaste dosage not only protects against cavities but also prevents fluoride overdose. The official recommendation for fluoride toothpaste is: pea-sized. Studies show that parents use significantly more toothpaste.ᐳ
The addition of fluoride in toothpaste is particularly controversial for children under 6 years of age. Children in particular swallow a large portion of their toothpaste.
The uncontrollable swallowing of fluoride toothpaste can be particularly harmful to children. Therefore, the common recommendation is to use a rice grain-sized amount of toothpaste.
An overdose can cause fluorosis.
With KAREX, swallowing toothpaste is no longer a risk. Swallowing the active ingredient BioHAP is completely safe and without risk.
Fluoroses are unsightly white spots on the teeth that are caused by excessive fluoride intake and remain for a lifetime.
While most children's toothpastes contain fluoride, KAREX toothpaste offers a modern alternative with BioHAP. This nature-inspired active ingredient works without fluoride and reduces the risk of fluorosis.
Brushing teeth with KAREX Toothpaste:
Especially young children cannot yet spit out toothpaste properly. Since KAREX Toothpastes are fluoride-free, there is no increased risk of fluorosis even if swallowed.
The active ingredient BioHAP is simply dissolved in the stomach and is safe even if swallowed.
Furthermore, special care was taken during the development of our toothpaste to use only necessary ingredients. Therefore, we deliberately avoid the use of sodium lauryl sulfate and titanium dioxide, for example.
BioHAP remineralizes teeth and protects against cavities
Reduces sensitivity associated with chalky teeth (MIH)
Allantoin soothes and protects the gums
Protects hard-to-reach areas – including around braces
BioHAP repairs the enamel and remineralizes small lesions evenly down into the underlying layers of the tooth.
In this way, BioHAP also protects against the development of new cavities.
The microcrystalline structure of BioHAP forms a protective layer on the tooth surface during dental care.
Acids and bacteria cannot attack the enamel directly.
During bacterial acid attacks, BioHAP releases calcium, which maintains the healthy mineralization of the enamel and reduces the tooth-damaging acidic pH value in the oral cavity.
The bacteria in the oral cavity are bound by BioHAP and prevented from forming a biofilm on the teeth – but not killed.
In this way, BioHAP helps to keep the oral flora in its natural balance.
Original article: edition.cnn.com
Original article: www.theguardian.com
Original article: www.newsweek.com
Numerous publications confirm the effectiveness of BioHAP in dental care. These include not only laboratory studies (in vitro) but also studies with test specimens under oral cavity conditions (in situ), as well as, in particular, clinical studies on patients (in vivo).
For more information, feel free to read the German short summary or the original study. You can get an overview of the large number of studies on Hydroxyapatite as an active ingredient in dental care by browsing our study database (usable without registration).
JUNIOR KAREX Toothpaste is recommended for all children from 6 years of age. The formula and mint flavor are optimally tailored to this age group’s preferences for a toothpaste and to the specific needs of the mixed dentition.
During the phase of tooth transition, the so-called mixed dentition consists of primary and permanent teeth. Both have different characteristics:
About 97% of our enamel and approx. 70% of our dentin consists of Hydroxyapatite. Enamel forms the outer protective layer of the teeth. Bacteria adhere to the enamel and, with the help of sugar from food, produce harmful acids. These acids dissolve the enamel: cavities develop.
JUNIOR KAREX Toothpaste contains the tooth-related active ingredient Hydroxyapatite, which deposits on the tooth while brushing. With daily brushing, even small defects in the enamel can be repaired by the active ingredient Hydroxyapatite, and a protective layer can be formed on the tooth. This protective layer makes it more difficult for bacteria to adhere to the tooth. JUNIOR KAREX with Hydroxyapatite thus provides effective protection against cavities.
During the development of JUNIOR KAREX Toothpaste, special care was taken to use only the necessary ingredients. JUNIOR KAREX Toothpaste contains Hydroxyapatite as the main active ingredient and is free from fluoride and free from sodium lauryl sulfate.
JUNIOR KAREX Toothpaste contains xylitol. Xylitol additionally helps to prevent cavities.
The active ingredient BioHAP contained in JUNIOR KAREX releases calcium during (bacterial) acid attacks. This protects the teeth from demineralization and supports remineralization (the re-incorporation of calcium and phosphate).
KINDER KAREX Toothpaste is specially developed for sensitive primary teeth. It provides gentle cleaning and effective cavity protection with BioHAP. Due to its mild formulation and child-friendly flavor, it is suitable from the eruption of the first tooth and is harmless even if swallowed. After all, children can only reliably spit out toothpaste once they reach elementary school age.
JUNIOR KAREX Toothpaste has been developed for the different oral care needs of primary teeth (very thin, sensitive enamel) and permanent teeth (increased plaque formation, especially when wearing fixed braces). The flavor has also been specially selected for older children. JUNIOR KAREX Toothpaste reliably removes plaque without attacking the enamel, additional calcium sources support natural remineralization and buffer acid attacks. This helps prevent cavities. Allantoin soothes stressed gums during tooth eruption and while wearing brackets (fixed braces).
The flavor contains very small amounts of menthol and eucalyptol. Please take this into account if your child is receiving homeopathic treatment.
No. JUNIOR KAREX Toothpaste does not contain wheat and can be used in cases of gluten intolerance.
No, JUNIOR KAREX Toothpaste does not contain nanoparticles.
JUNIOR KAREX Toothpaste does not contain any animal-derived ingredients and is therefore also suitable for vegans.
No, JUNIOR KAREX Toothpaste does not contain titanium dioxide.
