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    Screenshot of a Focus Online newspaper article titled "Alarming Studies: High Fluoride Content in Drinking Water Said to Significantly Reduce Children's IQ" on a dark blue background; to underline the headline "Always Convinced — With BioHAP Instead of Fluoride"Screenshot of a Focus Online newspaper article titled "Alarming Studies: High Fluoride Content in Drinking Water Said to Significantly Reduce Children's IQ" on a dark blue background; to underline the headline "Always Convinced — With BioHAP Instead of Fluoride"

    Always Convinced — With BioHAP Instead of Fluoride

    KAREXKAREX: BioHAP – The Next Generation of Tooth Protection

    ProductsProducts: Ideal for Children: Cavity Protection Without Risk

    The Direct Comparison

    A table comparing BioHAP and fluoride in the categories of cavity protection, swallowing, fluorosis protection, and suitability for chalky teeth (MIH). BioHAP offers advantages in all areas, while fluoride only matches BioHAP in cavity protection, but is inferior in all other categories.

    Fluoride RisksFluoride Risks: Fluoride Risks in Focus

    • Fluorosis

    • IQ Reduction

    • Risks During Pregnancy

    • Alzheimer's disease

    Background Information on Fluoride Risks

    BioHAPBioHAP: Modern Dental Care for Children: With KAREX and BioHAP

    What kind of active ingredient is BioHAP?

    RecommendedRecommended: Canadian Dental Association Confirms Efficacy of BioHAP Against Cavities

    Logo der kanadischen Zahnärztekammer (Canadian Dental Association) als Beleg dafür, dass KAREX die einige fluoridfreie Zahnpasta mit Hydroxylapatit ist, die in Kanada von der Health Canada zur Vorbeugung von Karies zugelassen ist

    The Benefits of BioHAP

    • Logos of the Max Planck Society, the Fraunhofer Institute, the Public Health Department of the City of Braunschweig, and Charité – Universitätsmedizin Berlin are arranged on a light blue background, symbolizing some of the research institutions that have published studies on Hydroxyapatite and BioHAP in oral care.

      Cavity protection proven by studies

    • A mother is sitting in the bathroom with her baby on her lap; the baby is holding a baby toothbrush in one hand and an open tube of BABY KAREX with BioHAP instead of fluoride in the other, symbolizing the appropriate oral care for babies.

      Safe use

    • A girl in a blue-and-white striped top smiles at the camera; white spots can be seen on her front teeth, which are signs of fluorosis, an enamel defect caused by excessive fluoride intake.

      Reduced risk of fluorosis

    zm online: FDA Warns: Fluoride Tablets for Children Are Risky
    zm online: FDA Warns: Fluoride Tablets for Children Are Risky
    focus: High Fluoride Content in Drinking Water Said to Significantly Reduce IQ in Children
    focus: High Fluoride Content in Drinking Water Said to Significantly Reduce IQ in Children
    New York Times: The Anti-Fluoride Movement Is Breaking Into the Mainstream
    New York Times: The Anti-Fluoride Movement Is Breaking Into the Mainstream
    CNN: Fluoride During Pregnancy May Harm Children
    CNN: Fluoride During Pregnancy May Harm Children
    The Guardian: US Authorities Want to Minimize Fluorosis Risks From Too Much Fluoride
    The Guardian: US Authorities Want to Minimize Fluorosis Risks From Too Much Fluoride

    ᑎ Fluoride Action Network (FAN), 2015. Submission to the National Toxicology Program: Review of fluoride for non-cancer health outcomes, including developmental neurotoxicity and endocrine disruption.

    ᐳ Bai, R., Huang, Y., Wang, F., & Guo, J., 2020. Associations of fluoride exposure with sex steroid hormones among U.S. children and adolescents, NHANES 2013–2016. Environmental Pollution, 260, p.114003. doi: 10.1016/j.envpol.2020.114003.

    ᑐ National Institute of Dental and Cranofacial Research: The Story of Fluoridation

    ᕒ Pawinska, M., Paszynska, E., Amaechi, B. T., Meyer, F., Enax, J., & Limeback, H. (2024): Clinical evidence of caries prevention by hydroxyapatite: An updated systematic review and meta-analysis. Journal of Dentistry, 151

    Learn More

    Clinically confirmed: KINDER KAREX Toothpaste is the first and only fluoride-free toothpaste with Hydroxyapatite to be approved in Canada by the health authorities (Health Canada) as an anti-cavity toothpaste. It is therefore a so-called "Natural Health Product." This product status can only be achieved when scientifically sound clinical data on efficacy and safety are available. In addition, the efficacy of the toothpaste with Hydroxyapatite has been confirmed by the Canadian Dental Association (CDA).

    Fluoride has long been used in cavity prevention, but it can carry risks — especially for children. KAREX is therefore taking a new approach: We rely on BioHAP, the scientifically proven active ingredient that prevents cavities just as effectively as fluoride — but without the risks. This makes KAREX the modern, safe choice for tooth protection for everyone — from the very first tooth.

    To the studies
    Canadian Dental Association Confirms Efficacy

    BioHAP stands for biomimetic Hydroxyapatite — the main component of our natural tooth enamel.

    BioHAP helps protect against cavities and remineralize damaged tooth enamel.

    Learn more about BioHAP

    Numerous scientific publications confirm the effect of Hydroxyapatite in oral care. BioHAP is at least as effective as fluoride in cavity prevention.

    Learn more

    Small children usually cannot spit out toothpaste properly yet and swallow a large portion of it – with BioHAP this is harmless. No strict dosage requirements as with fluoride-containing toothpastes.

    The permanent damage to tooth enamel (fluorosis) is caused by an overdose of fluoride. KAREX is effective without fluoride. Toothpaste with BioHAP can be swallowed without hesitation.

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    Logo KAREX
    Logo KAREX
    • BioHAP instead of fluoride
      • Fluoride Risks
        Fluoride Risks
        • What is BioHAP?
          What is BioHAP?
        • Baby & Mama
          • Products
            • BABY KAREX toothpaste
            • MAMA KAREX toothpaste
            • KAREX toothpaste
            • View all
          • Dental care tips
            • Teething in babies: Help & tips when babies are getting their teeth
            • The first dental care: From when should you start brushing your baby's teeth?
            • Tips for toothache during pregnancy
        • Kids
          • Products
            • KINDER KAREX toothpaste
            • KAREX tooth protection gel
            • View all
          • Tips for healthy baby teeth
            • Cavities in children: Tips for prevention and proper dental care
            • Fluorosis: What are the white spots on the teeth?
            • More guides
        • Junior
          • Products
            • JUNIOR KAREX toothpaste
            • KAREX tooth protection gel
            • View all
          • Tips for permanent teeth
            • Tooth loss in children: A closer look at the mixed dentition
            • Chalk teeth in children: Symptoms, causes, and treatment
            • More guides
        • Research
          • Research at Dr. Wolff
            Research at Dr. Wolff
            • BioHAP Studies
              BioHAP Studies
              • Benefits of fluoride-free toothpastes with BioHAP
                Benefits of fluoride-free toothpastes with BioHAP
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                About KAREX
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                de - English
                Zwei Tuben KINDER KAREX Zahnpasta, Aufschrift: „Zahnpasta mit BioHAP ohne Fluorid. Biomimetischer Hydroxylapatit“.

                KINDER KAREX toothpaste

                2-pack

                5 / 5 (1)
                €8.98100 ml (€89.80 / 1 l) • incl. VAT, plus shipping
                Zwei Tuben JUNIOR KAREX Zahnpasta, Aufschrift: „Zahnpasta mit BioHAP ohne Fluorid. Biomimetischer Hydroxylapatit“.

                JUNIOR KAREX toothpaste

                2-pack

                5 / 5 (1)
                €9.98130 ml (€76.77 / 1 l) • incl. VAT, plus shipping
                Zwei Tuben KAREX Zahnpasta, „Ohne Fluorid“ und „Wirksamer Kariesschutz mit BioHAP statt Fluorid. Biomimetischer Hydroxylapatit“.

                KAREX toothpaste

                2-pack

                5 / 5 (40)
                €11.98150 ml (€79.87 / 1 l) • incl. VAT, plus shipping
                Zwei Tuben BABY KAREX Zahnpasta, Aufschrift: „Zahnpasta mit BioHAP ohne Fluorid. Biomimetischer Hydroxylapatit“.

                BABY KAREX toothpaste

                2-pack

                €9.98100 ml (€99.80 / 1 l) • incl. VAT, plus shipping
                Zwei Tuben MAMA KAREX Zahnpasta, Aufschrift: „Zahnpasta mit BioHAP ohne Fluorid. Biomimetischer Hydroxylapatit“.

                MAMA KAREX toothpaste

                2-pack

                5 / 5 (5)
                €11.98150 ml (€79.87 / 1 l) • incl. VAT, plus shipping
                Zwei Tuben KAREX Zahnschutzgel, Aufschrift: „Zahnschutzgel mit BioHAP ohne Fluorid. Biomimetischer Hydroxylapatit“.

                KAREX tooth protection gel

                2-pack

                5 / 5 (12)
                €17.98100 ml (€179.80 / 1 l) • incl. VAT, plus shipping

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