Clinically proven: lasting short-term effects


Sensitive teeth and tooth necks are problems that are becoming more and more prevalent in modern society. In order for patients to maintain a high quality of life and keep pain as low as possible, relevant applications in the form of toothpastes and mouthwashes should have an effect in the short term and maintain this effect in the long term.


Does hydroxyapatite have an effect on pain-sensitive teeth and how quickly can this be measured?

Material and methods

Two clinical studies were conducted to measure the effect of hydroxyapatite on pain-sensitive teeth. Both were double-blind and randomised studies. The test subjects were divided up into groups at random and were given toothpastes for pain-sensitive teeth to use over a period of 3 days or 8 weeks. One of these toothpastes contained hydroxyapatite. At the end of the study and during follow-up visits, tooth sensitivity was checked using various tests. This included tactile tests, air, heat and cold.


Very positive results could be obtained with the hydroxyapatite toothpaste, both in the study that reviewed sensitivity after three days as well as in the long-term study. A reduction in sensitivity could be detected in the majority of patients after just 3 days, which was also present after 8 weeks.


The regular application of a hydroxyapatite toothpaste clinically reduces sensitivity after three days of application. Hydroxyapatite is also effective in the long term for sensitive teeth.

The publication of the study can be found here.


Sources: Orsini, G., M. Procaccini, L. Manzoli, F. Giuliodori, A. Lorenzini and A. Putignano (2010). “A double-blind randomized-controlled trial comparing the desensitizing efficacy of a new dentifrice containing carbonate/hydroxyapatite nanocrystals and a sodium fluoride/potassium nitrate dentifrice.” J. Clin. Periodontol. 37: 510-517. Orsini, G., M. Procaccini, L. Manzoli, S. Sparabombe, P. Tiriduzzi, F. Bambini and A. Putignano (2013). “A 3-day randomized clinical trial to investigate the desensitizing properties of three dentifrices.” J. Periodontol. 84: 65-73.